The Expression of Surun Leptin in Colorectal Cancer Archive ...

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Tumor Research

[Abstract]

ObjectiveObesity has been shown to be associated with an increased risk of colorectal cancer.One mechanism underlying this relationship may involve the grow-promoting effects of the circulating hormone associated with obesity,such as leptin.The investigation is to investigate the relationships of leptin level in serum and colorectal carcinoma.MethodsABC-ELLSA was used to detect the leptin level in 30 colorectal patients and 24 normal controls.The K-RAS?P53?APC?DCC genes of the tumors were examined with RT-PCR,and other clinicopathological features were also recorded.ResultsThe leptin level in 30 colorectal patients are(3.54(2.08?5.01)ng/mL)higher than the contral normal group(2.27(1.28?3.26)ng/mL),p?0.05.There were no significant difference between the each tumor stages leptin level.Leptin level in patients who are poorly differentiated is obviously lower than those in who are well-differentiated and moderately differentiated.There were no significant difference with the level of CEA and CA199.There were no significant difference with K-RAS?P53?APC?DCC genes in tumor.ConclusionThe leptin level in colorectal patients are higher than the normal persons.The differentiated of tumor chang the leptin level.There were no significant correlations between K-RAS?P53?APC?DCC genes in tumor and leptin in serum.

Title: The Expression of Surun Leptin in Colorectal Cancer

Category: Tumor Immunology

Filename: The Expression of Surun Leptin in Colorectal Cancer.pdf

Pages: 150

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